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What happens if I miss a dose?
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Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.
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What happens if I overdose?
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Seek emergency medical attention.
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Symptoms of a hydralazine and hydrochlorothiazide overdose include very low blood pressure (fainting, dizziness, confusion), an irregular heartbeat, headache, increased urination, vomiting, diarrhea, and flushing of the skin.
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What should I avoid while taking hydralazine and hydrochlorothiazide?
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Use caution when driving, operating machinery, or performing other hazardous activities. Hydralazine and hydrochlorothiazide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
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Stand up slowly from a sitting or lying position. Hydralazine and hydrochlorothiazide may make you feel dizzy.
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Avoid alcohol while taking hydralazine and hydrochlorothiazide. Alcohol may increase the drowsiness caused by hydralazine and hydrochlorothiazide and may also increase dizziness. Use caution even with small amounts of alcohol.
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Discuss with your doctor the amount of salt in your diet. Too much salt may cause your body to retain water and may decrease the effects of hydralazine and hydrochlorothiazide. Talk to your doctor before increasing or decreasing the amount of salt in your diet.
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Do not let yourself become overheated in hot weather or during exercise, and use caution if you have a fever. These situations increase the effects of hydralazine and hydrochlorothiazide, and you may become very dizzy.
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Avoid prolonged exposure to sunlight. Hydrochlorothiazide may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.
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What are the possible side effects of hydralazine and hydrochlorothiazide?
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If you experience any of the following serious side effects, stop taking hydralazine and hydrochlorothiazide and seek emergency medical attention:
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an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
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abnormal bleeding or bruising;
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blood in your urine or stools;
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numbness, tingling, pain, or weakness of your arms or legs;
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heart failure (shortness of breath, swelling of ankles or legs, weight gain of 2 pounds in one day or 5 pounds in one week);
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irregular or fast heartbeats or a fluttering feeling in your chest;
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new or worsening chest pain; or
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Other, less serious side effects may be more likely to occur. Continue to take hydralazine and hydrochlorothiazide and talk to your doctor if you experience
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dizziness, especially upon changing position (e.g., when you sit or stand up from a lying position);
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muscle weakness or cramps;
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increased hunger or thirst;
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nausea, vomiting, diarrhea, or decreased appetite;
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sensitivity to sunlight;
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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
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What other drugs will affect hydralazine and hydrochlorothiazide?
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Before taking this medication, tell your doctor if you are taking any of the following drugs:
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a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
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a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
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a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), or tolbutamide (Orinase);
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a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron, Hexadrol), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others;
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lithium (Lithobid, Eskalith, others); or
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digoxin (Lanoxin, Lanoxicaps).
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You may not be able to take hydralazine and hydrochlorothiazide, or you may require a lower dose or special monitoring during treatment if you are taking any of the medicines listed above.
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Also, before taking hydralazine and hydrochlorothiazide, tell your doctor if you are taking any medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition. Some of these medicines may interact with hydralazine and hydrochlorothiazide, and the interaction may increase the effects on your heart.
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Hydralazine and hydrochlorothiazide may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.
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Drugs other than those listed here may also interact with hydralazine and hydrochlorothiazide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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